Lamotrigine in Rett syndrome: brands, slow introduction and side effects

[admin]

Generic medicine: LamotrigineCommon brand name: Lamictal. Generic versions are widely available.
Brand names and formulations vary by country.

How it may be used
Lamotrigine is a broad-spectrum antiseizure medicine and has been among the medicines frequently used in Rett syndrome. Retrospective Rett studies suggest it can be useful for some people, including some whose epilepsy begins later, but individual response varies.

Why it is introduced slowly
The dose normally increases gradually to reduce the risk of a serious rash. Valproate raises lamotrigine levels, so the titration and dose are different when they are used together.

Common side effects
• Headache
• Dizziness, drowsiness or tiredness
• Feeling sick or vomiting
• Tremor
• Blurred or double vision
• Difficulty sleeping
• Mild rash

Important risks
• Serious skin reactions such as Stevens–Johnson syndrome or toxic epidermal necrolysis
• DRESS, a severe reaction that may involve fever, rash, swollen glands and internal organs
• Aseptic meningitis
• Rare blood or liver problems
• Heart-rhythm caution in people with certain structural or conduction disorders

Seek urgent medical advice for
Any new rash—especially with fever, mouth sores, blistering, facial swelling or swollen glands—severe headache with stiff neck, jaundice, unusual bruising, fainting or a new abnormal heartbeat.

Important: Do not restart lamotrigine at the previous dose after several missed days without asking the prescriber. Never stop it suddenly.

Rett-specific evidence: https://pubmed.ncbi.nlm.nih.gov/25814391/
Medicine information: https://www.nhs.uk/medicines/lamotrigine/

Information checked 4 September 2026. This is general information, not a complete side-effect list or prescribing advice. Contact the neurology team about any rash or dose interruption.